Accelerate Biopharmaceutical Characterization & Quantification

Protein Metrics provides vendor-neutral mass spectrometry software for comprehensive protein and oligo analysis across the development process
Trusted by over 500 biopharma and academic organizations
Leading Mass Spectrometry Data Analysis Software
Protein Metrics is the preferred vendor-neutral company offering advanced protein characterization solutions for the laboratory and the enterprise.
Vendor Neutral
All Platforms, One Dedicated Software

Instrument agnostic mass spec software allows you to use data generated on all major commercially available mass spectrometry platforms to quickly identify and characterize proteins.

A clean, clear user interface provides intuitive access to the protein data analysis tools needed so you can enjoy your science and not be frustrated by software.

All Platforms, One Dedicated Software
Identify, Characterize, and Quantify Your Proteins
Comprehensive Analysis
Identify, Characterize, and Quantify Your Proteins

Protein Metrics offers the most comprehensive, accurate analysis of your mass spec data, quantifying species down to trace amounts.

Unique algorithms help minimize ambiguity, achieve reproducibility, and eliminate lab-to-lab variability.

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Fast Workflow Automation
Automate Your Protein Analysis for Efficient, Reproducible Results

Run automated workflows for a broad range of mass spec analysis, including intact, peptide, chromatogram and oligo analysis.

Process multiple protein samples consistently in a hands-free manner, and create ready-to-deliver reports in minutes.

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Automate Your Protein Analysis for Efficient, Reproducible Results
View, Analyze and Report Data Across Projects
View, Analyze and Report Data Across Projects

Manage, interrogate, and share files and reports generated from any analytical lab.

Easily find past experiments, reuse knowledge and unearth fresh insights with metadata, deep query and dashboards processing the most up-to-date information.

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Bench-to-Enterprise Software for Biotherapeutic Analysis
Protein Metrics supports protein identification, characterization and reporting across the entire development process with a range of products available to suit your current and future needs.
  • Byonic
  • Byos
  • Byosphere
Peptide and Protein Identification
Peptide and Protein Identification

Byonic™ is a full MS/MS search engine providing unequaled sensitivity for comprehensive peptide and protein identification.

Byonic Protein Identification Software
Biologics Characterization and Reporting
Biologics Characterization and Reporting

Byos® desktop software offers comprehensive analysis workflows providing the most robust protein characterization and reporting available.

Byos Protein Characterization Software
Dashboards, Deep Querying and Analytics
Dashboards, Deep Querying and Analytics

Byosphere enterprise platform combines biotherapeutic mass spec data, analysis, and reporting in one cloud environment. Byosphere lets you curate, interrogate, and share information gained from Byos.

Byosphere Enterprise Platform

“Protein Metrics software is a powerful tool for analyzing glycosylation and other PTMS. Their software greatly alleviates the mass spec analysis bottleneck.”

Wilson Phung Scientific Researcher, Genentech

“This is the workflow/software that I have been wanting for over a decade. I just completed a large comparability study for a glycoprotein that has both N-linked and O-linked glycosylation. Compared to what my workflow used to be with the software my MS vendor sold, the process with Byonic™, Byologic®, and ByoMap™ was much more efficient and straightforward. Byologic gives the user ready access to all pertinent information for each peptide, and ByoMap helps me generate informative comparability chromatograms very quickly. Also, in a project like this, I spend a great deal of time writing reports for people who are not necessarily MS-savvy. Once I learned how to use and customize reports in Byologic and ByoMap, that process was streamlined as well.”

Kevin Van Cott, Ph.D. Associate Professor, University of Nebraska, Lincoln, Chemical and Biomolecular Engineering

“With Byologic® I replaced six different analytical LC/MS Peptide map methods (six analysts doing six methods) with one MS method. We transferred it to the High Throughput Screening group. They can run that one method faster than it used to take one analyst to run an individual method, and we can generate and ask questions much more quickly.

Using Protein Metrics software, we can also run cell-culture samples directly in days. Prior to implementing their software, it took us six months to send samples to purification and then analyze them.”

Matt Traylor, Ph.D. Associate Director, Analytical Development, Takeda

“I really like the Protein Metrics software. It helped us to make advances that we may not have been able to with other software. It identified protein impurities that we couldn’t make with other software. I was impressed with the auto reporting features and search engine. We realized cost savings and were able to reallocate resources. We can now get deeper into our to data to find what we’re looking for. The people are really great to deal with – Eric and the team – fantastic, we get a very good response from them.”

Mimi Roy, Ph.D. Sr. Director, Analytical DevelopmentAmerican biotech focused on enzyme replacement therapies

“Our mission is to push science forward as much as we can, and Protein Metrics software helps us accomplish this. Particularly, we find their Intact Mass™ software simple to use but also powerful and flexible, so we expect to utilize it further.”

Yury Tsybin, Ph.D. CEO, Spectroswiss

“I wanted to let you know that Byonic™ is fantastic. I am very impressed; it’s the best search engine I have ever used. I have some rock solid head-to-head comparisons vs. other protein analysis software.”

Laurence Brill, Ph.D. Senior Scientist, Intertek

“Protein Metrics’ Byonic™ software is a powerful proteomics tool. Relative to other search engines such as Sequest and Mascot, we have observed a significant gain in speed and overall peptide identifications. Byonic is especially powerful in identifying isobarically tagged peptides and peptide PTMs, such as glycosylation. Byonic has become the primary tool for peptide identification in our lab and provides our research collaborators with the most robust data sets.”

Chris Adams, Ph.D. Director of Proteomics, Stanford University Mass Spectrometry, Stanford University

“Byonic™ very quickly became the search engine of choice in my lab as it handles CAD, HCD and ETD data equally well and superior to other search engines we have used. We especially came to rely on the precision with which Byonic identifies PTMs and even unanticipated modifications and sequence variants. Several projects in my lab depend on Byonic’s Wildcard search that allows us to place a large mass window on a specific or all amino acids without decreasing the sensitivity of our search. Using the wildcard modification in combination with Byonic’s integrated top down search became a game changer for our lab. We are now routinely characterizing complex mixtures of 8kDa proteins from organisms with incomplete database in a top down manner without fractionation or sub-digestion. Not only do we identify exact matches to RNA-Seq data, but we also identify numerous additional sequence variants and PTMs all top down. The exhaustive annotation of Byonic makes it incredibly easy to rapidly validate the identifications. Truly Byonic is the one-stop-shop for exhaustive protein characterization from top to bottom.”

Beatrix Ueberheide, Ph.D. Assistant Professor, Department of Biochemistry and Molecular Pharmacology, NYU Langone Medical Center

“…[Protein Metrics] is quietly writing the best shotgun proteomics software I have ever seen….”

Benjamin Orsburn, Ph.D. Senior Application Scientist, Proteomics News Blog

“For us, Byonic™ has opened new windows in the study of cardiovascular disease.”

Manuel Mayr M.D., Ph.D. Professor of Cardiovascular Proteomics, King’s College London

“Protein Metrics’ Byonic™ has changed the way we evaluate our data and even do our up front experiments. The ability of this program to address mass spectra of glycopeptides directly is a Game Changer. No other program that I am aware of, and we have used many, can compete for assigning glycopeptides. This is not to mention the speed of the searches that are phenomenal….Byonic runs a search faster looking for multiple modifications than the previous program we were using allowing for no modifications!”

Lance Wells, Ph.D. Prof. Biochem. and Mol. Biol., University of Georgia

“It’s great for our field to have a single search engine, Byonic™ which excels at all the different proteomics methods — data-dependent, data-independent, bottom-up, top-down, glycoproteins, and phosphoproteins.”

Michael MacCoss, Ph.D. Assoc. Professor of Genome Sciences, University of Washington School of Medicine

“Byonic™ has enabled us to evaluate complex tissues and biofluids at the glycopeptide level, allowing simultaneous glycan composition and peptide identification determinations. Using Byonic in our analytical workflow has greatly facilitated evaluation of known key biomarker glycoproteins like PSA, and also improved our ability to discover new cancer biomarker candidates. Additionally, the Protein Metrics staff have been exceptionally helpful in assisting with any software and data analysis questions that we have had, as well as troubleshooting different experimental approaches.”

Richard Drake, Ph.D. Professor and Director, Medical University of South Carolina Proteomics Center

“Byonic™ and Preview™ have become integral tools for our discovery proteomics pipeline. Searches are rapid, customizable, statistically validated and highly informative. One of the best aspects is the ability to interface with the vendor and its programmers directly for advice on configurations and for collaborative implementation of new features.”

Mark Flory, Ph.D. Principal Scientist, Igenica, Inc.

“In my research, we are always looking for unexpected modifications to our proteins. Protein Metrics’ Byonic™ software has allowed us to find modifications that we haven’t even considered before. With other software products we have used we were only able to find what we already knew was there.”

Joshua S. Sharp, Ph.D. Assistant Research Scientist, University of Georgia

“…[Preview™ quickly evaluates your RAW data and gives you an idea of how you should be setting up your searches…this software is very very fast.”

Benjamin Orsburn, Ph.D. Senior Application Scientist, Proteomics News Blog