Resources
Explore our educational resources to advance your knowledge of Protein Metrics
Types
Categories
Getting Started

GUIDEQuick Start Guide to Peptide Analysis
Getting started with HCP, HotSpot, PTM, SVA, S-S, MAM new peak detection, system suitability, and oxidative footprinting workflows.

GUIDEQuick Start Guide to Intact Analysis
An easy guide to getting started with intact, reduced, ADC, intact reconstruction, and IntaBio icIEF-MS workflows.

GUIDEQuick Start Guide to Chromatogram Analysis
An easy guide to getting started with chromatography workflows, including reference, characterization and in-silico chromatography.

GUIDEQuick Guide to Oligonucleotide Analysis
Learn how to get started with oligonucleotide analysis, including digested oligonucleotide analysis.

GUIDEQuick Start Guide to Multi-Protein Analysis
An easy guide to getting started with multi-protein quantitation, multi-protein identification, and multi-protein preview workflows.

GUIDEQuick Start Guide to HDX Workflows
An easy guide to getting started with HDX analysis, including all our HDX workflows.

GUIDEQuick Start Guide to Released Glycan Analysis
Getting started with released glycan (N-linked), released glycan (O-linked), and released glycan (IgG) workflows.

GUIDEQuick Start Guide to Charge Variant Analysis
Follow this short guide and learn how to get started with change variant analysis with reconstruction.

GUIDEQuick Start Guide to De Novo Sequence Analysis
An easy guide to getting started with de novo sequence analysis workflows.

GUIDEQuick Start Guide to HRIM Analysis
Follow this short guide and learn how to get started with MOBILion High-Resolution Ion Mobility (HRIM) analysis.
Video Tutorials

VIDEO SERIESUsing Byonic
The Byonic tutorials explain MS/MS integration, peptide searches, charge adjustments, filtering PSMs, and report generation.

VIDEO SERIESUsing Byosphere
Byosphere enhances LC-MS analysis with custom searches, dashboards, automated workflows, audit trails, and project management.

VIDEO SERIESByosphere Dashboards
Byosphere dashboards turn complex LC-MS datasets into interactive views — track results, compare batches, and monitor trends in one place.

VIDEO SERIESWorking with Peptide Workflows
Explore peptide workflows, set up searches, interpret scores, validate peptides, manage disulfide mapping, and create reports.

VIDEO SERIESWorking with Intact Mass Workflows
Run intact mass workflows in Byos. Manage data, sequences, masses, deconvolution, and generate reports for ADCs, glycosylation, and oligos.

VIDEO SERIESWorking with Disulfides
Learn how to manage disulfide workflows, add samples, define sequences, create disulfide bridge and validate linked peptides.

VIDEO SERIESWorking with Chromatogram Workflows
Learn to use chromatogram workflows for peak analysis, adjust baselines, integrate peaks, align traces, and explore glycan analysis.

VIDEO SERIESWorking with Multi-Protein Quantitation
Rapidly analyze MS data to quantify proteins, manage workflows, and validate peptides in complex samples.

VIDEO SERIESWorking with Released Glycan Workflows
Learn to use released glycan workflows for N-glycans, O-glycans, and IGG glycans. Explore Glycan cartoons for visual representation.

VIDEO SERIESWorking with Oligonucleotide Workflows
Learn how to automate oligonucleotide data processing, handle raw files, define sequences, and generate custom reports.

VIDEO SERIESWorking with Digested Oligo Workflows
Learn Byos Digested Oligonucleotide workflows, modification setup, investigation tools, and custom report creation.

VIDEO SERIESWorking with Hydrogen Deuterium Exchange (HDX)
The HDX tutorial series explains how to set up HDX workflows, analyze deuterium uptake, and generate detailed protein reports.

VIDEO SERIESWorking with Reconstruction Workflows
Perform intact reconstruction and charge variant analysis. Set up projects, configure processing nodes, and align CIEF traces effectively.
Research Spotlight

VIDEO SERIESResearch Spotlights
See how are customers have been applying our software in real world scenarios - short videos to give you the essential highlights,

VIDEO SERIESResearch Spotlight on Peptides
Watch these spotlight videos on peptides covering methods for mapping, quantitation, glycosylation, and antibody stability.

VIDEO SERIESResearch Spotlight on Multispecifics
The latest in multispecifics with videos on bispecific antibody stability, mispairing, and effective characterization methods.

VIDEO SERIESResearch Spotlight on Disulfides
Watch these spotlight videos on rapid cross-link detection, bacterial microcompartment assembly, and bond stability in proteins.

VIDEO SERIESResearch Spotlight on Glycopeptides
Watch these spotlight videos on glycosylation analysis techniques, covering protein glycan structures and SARS-CoV-2 applications.

VIDEO SERIESResearch Spotlight on Intact Mass
Watch this video on a novel serum stability assay, enhancing accuracy in biologics screening with in vitro methods.

VIDEO SERIESResearch Spotlight on Higher Order Structure
Explore higher-order structure in these videos on plasma-induced modification and bacterial microcompartment assembly insights.

VIDEO SERIESResearch Spotlight on De Novo
This video series covers research on advanced mass spectrometry techniques for accurate antibody and protein structure analysis.
Publications

PUBLICATIONHow to Unlock the Power of Peptide Analysis with Byos
Master advanced peptide analysis with Byos. Learn expert techniques for PTM searches, glycopeptide characterization, and quantification workflows.

PUBLICATIONLab of the Future: Fully Automated System for High-Throughput Mass Spec Analysis
A state-of-the-art, integrated, multi-instrument automated system for MS characterization of biotherapeutics.

PUBLICATIONParsimonious Charge Deconvolution for Native Mass Spectrometry
A new “parsimonious” charge deconvolution algorithm well-suited to high-resolution native MS of intact glycoproteins and protein complexes.

PUBLICATIONMulti-Protein Quantitation Workflow Tools for Host Cell Protein Discovery
The new multi-protein quantitation mass spectrometric analysis workflow tools for discovery-phase protein scientists.

PUBLICATIONAutomated Antibody De Novo Sequencing and Its Utility in Biopharma Discovery
A novel method to automatically de novo sequence antibodies using mass spec and Byos, and a demonstration of algorithm robustness.

PUBLICATIONOrthogonal Comparison of Analytical Methods by Theoretical Reconstruction from Bottom-up Assay Data
Bottom-up methods like peptide mapping can be used to build reconstructions of both theoretical intact mass spectra and theoretical electropherograms.

PUBLICATIONPeak Filtering, Peak Annotation, and Wildcard Search for Glycoproteomics
Improvements to Byonic, a glycoproteomics search program, that addresses the analytical and bioinformatics challenges glycopeptide analysis poses.

PUBLICATIONByonic: Advanced Peptide and Protein Identification Software
Byonic is a new software package for peptide and protein identification by tandem mass spectrometry, facilitating a wide range of search possibilities

PUBLICATIONGold Standard in Glyco Peptide Search
HGI study in Nature Methods evaluating glycoproteomics informatics solutions and high-performance search strategies for serum glycopeptide analysis

PUBLICATIONAutomate and Simplify Oligonucleotide Analysis by Mass Spectrometry
Discover how you can use Protein Metrics software to automate and simplify the analysis of data from Oligonucleotide analysis by mass spectrometry.

PUBLICATIONPreview: A Program for Surveying Shotgun Proteomics Tandem Mass Spectrometry Data
Preview analyzes a set of mass spectra for mass errors, digestion specificity, and known and unknown modifications to facilitate parameter selection.

PUBLICATIONTwo-Dimensional Target Decoy Strategy for Shotgun Proteomics
New target-decoy strategy estimates and controls PSM and protein FDRs simultaneously, regardless of the relative numbers of spectra and proteins.
On Demand Webinars

WEBINARDecoding IgG2 Disulfide Isoforms with Native CEX-MS and Advanced Peptide Mapping
Blueprints to Results: Mapping IgG2 Structural Complexity

WEBINARAutomating Peptide Mapping: From Bench to Batch in Half the Time
How Genentech combined liquid handling automation with Byos software to save 2-3 days per week across disulfide, PTM, and glycation workflows

WEBINARRapid and flexible analytical characterization of oligonucleotides
Advancing LC-UV-MS workflows with Byos for high-throughput oligonucleotide characterization in early drug discovery

WEBINAREvaluation of Multi-Protein Quantitation Workflow for Host Cell Protein Analysis
What's hiding inside? A new multi-protein workflow uncovers the unexpected in HCP analysis

WEBINARMS Analysis of Intact Oligonucleotides
Explore advanced workflows for oligonucleotide analysis, focusing on fragmentation and MS2 annotation.

WEBINARStreamlining CHO HCP Analysis with Byos Multi-Protein Quantitation
Discover how Byos enables sensitive, label-free HCP quantitation across CHO downstream steps—fast, scalable, and reproducible.

WEBINARA Sweet Solution for MS Glycan Analysis
Streamline glycoprotein QC: discover automated MS glycan grouping for faster, clearer biotherapeutic insight in development today

WEBINARAutomated High-Throughput Screening Using Native MS
Spot the winner in a crowded sky: Automated native MS for rapid hit discovery

WEBINARIntact Characterization of Multispecifics
Learn about multispecific antibodies and the use of 2D LC-MS for improved production and analysis.

WEBINARThe Glycan Code of Immunity and Cancer
Paucimannose isn’t just metabolic noise. Learn how glycan profiling in immune cells and cancer tissue reveals hidden layers of disease biology.

WEBINARComprehensive ADC Analysis via Automated MS Workflows
Automated workflows for analyzing antibody-drug conjugates, from fractionation and digestion to high-sensitivity nanoflow LC-MS/MS.
Japanese Resources

WEBINAR医薬品オリゴヌクレオチド分析の課題に対するソリューション
本セミナーでは、アジレントテクノロジーとプロテインメトリックスにおける、核酸医薬品LC,LCMS分析の最新ソリューションについてお話しします

WEBINAR効率的なMAM解析
タンパク質マトリックス MAM 分析プラットフォーム「Byos」および「Byosphere」をご覧ください。ライブデモやQ&Aも予定されています。