Resources

Explore our educational resources to advance your knowledge of Protein Metrics

Getting Started

Getting started with HCP, HotSpot, PTM, SVA, S-S, MAM new peak detection, system suitability, and oxidative footprinting workflows.
An easy guide to getting started with intact, reduced, ADC, intact reconstruction, and IntaBio icIEF-MS workflows.
An easy guide to getting started with chromatography workflows, including reference, characterization and in-silico chromatography.
Learn how to get started with oligonucleotide analysis, including digested oligonucleotide analysis.
An easy guide to getting started with multi-protein quantitation, multi-protein identification, and multi-protein preview workflows.
An easy guide to getting started with HDX analysis, including all our HDX workflows.
Getting started with released glycan (N-linked), released glycan (O-linked), and released glycan (IgG) workflows.
Follow this short guide and learn how to get started with change variant analysis with reconstruction.
An easy guide to getting started with de novo sequence analysis workflows.
Follow this short guide and learn how to get started with MOBILion High-Resolution Ion Mobility (HRIM) analysis.

Video Tutorials

The Byonic tutorials explain MS/MS integration, peptide searches, charge adjustments, filtering PSMs, and report generation.
Byosphere enhances LC-MS analysis with custom searches, dashboards, automated workflows, audit trails, and project management.
Byosphere dashboards turn complex LC-MS datasets into interactive views — track results, compare batches, and monitor trends in one place.
Explore peptide workflows, set up searches, interpret scores, validate peptides, manage disulfide mapping, and create reports.
Run intact mass workflows in Byos. Manage data, sequences, masses, deconvolution, and generate reports for ADCs, glycosylation, and oligos.
Learn how to manage disulfide workflows, add samples, define sequences, create disulfide bridge and validate linked peptides.
Learn to use chromatogram workflows for peak analysis, adjust baselines, integrate peaks, align traces, and explore glycan analysis.
Rapidly analyze MS data to quantify proteins, manage workflows, and validate peptides in complex samples.
Learn to use released glycan workflows for N-glycans, O-glycans, and IGG glycans. Explore Glycan cartoons for visual representation.
Learn how to automate oligonucleotide data processing, handle raw files, define sequences, and generate custom reports.
Learn Byos Digested Oligonucleotide workflows, modification setup, investigation tools, and custom report creation.
The HDX tutorial series explains how to set up HDX workflows, analyze deuterium uptake, and generate detailed protein reports.
Perform intact reconstruction and charge variant analysis. Set up projects, configure processing nodes, and align CIEF traces effectively.

Research Spotlight

See how are customers have been applying our software in real world scenarios - short videos to give you the essential highlights,
Watch these spotlight videos on peptides covering methods for mapping, quantitation, glycosylation, and antibody stability.
The latest in multispecifics with videos on bispecific antibody stability, mispairing, and effective characterization methods.
Watch these spotlight videos on rapid cross-link detection, bacterial microcompartment assembly, and bond stability in proteins.
Watch these spotlight videos on glycosylation analysis techniques, covering protein glycan structures and SARS-CoV-2 applications.
Watch this video on a novel serum stability assay, enhancing accuracy in biologics screening with in vitro methods.
Explore higher-order structure in these videos on plasma-induced modification and bacterial microcompartment assembly insights.
This video series covers research on advanced mass spectrometry techniques for accurate antibody and protein structure analysis.

Publications

Master advanced peptide analysis with Byos. Learn expert techniques for PTM searches, glycopeptide characterization, and quantification workflows.
A state-of-the-art, integrated, multi-instrument automated system for MS characterization of biotherapeutics.
A new “parsimonious” charge deconvolution algorithm well-suited to high-resolution native MS of intact glycoproteins and protein complexes.
The new multi-protein quantitation mass spectrometric analysis workflow tools for discovery-phase protein scientists.
A novel method to automatically de novo sequence antibodies using mass spec and Byos, and a demonstration of algorithm robustness.
Bottom-up methods like peptide mapping can be used to build reconstructions of both theoretical intact mass spectra and theoretical electropherograms.
Improvements to Byonic, a glycoproteomics search program, that addresses the analytical and bioinformatics challenges glycopeptide analysis poses.
Byonic is a new software package for peptide and protein identification by tandem mass spectrometry, facilitating a wide range of search possibilities
HGI study in Nature Methods evaluating glycoproteomics informatics solutions and high-performance search strategies for serum glycopeptide analysis
Discover how you can use Protein Metrics software to automate and simplify the analysis of data from Oligonucleotide analysis by mass spectrometry.
Preview analyzes a set of mass spectra for mass errors, digestion specificity, and known and unknown modifications to facilitate parameter selection. 
New target-decoy strategy estimates and controls PSM and protein FDRs simultaneously, regardless of the relative numbers of spectra and proteins.

On Demand Webinars

How Genentech combined liquid handling automation with Byos software to save 2-3 days per week across disulfide, PTM, and glycation workflows
Advancing LC-UV-MS workflows with Byos for high-throughput oligonucleotide characterization in early drug discovery
What's hiding inside? A new multi-protein workflow uncovers the unexpected in HCP analysis
Explore advanced workflows for oligonucleotide analysis, focusing on fragmentation and MS2 annotation.
Discover how Byos enables sensitive, label-free HCP quantitation across CHO downstream steps—fast, scalable, and reproducible.
Streamline glycoprotein QC: discover automated MS glycan grouping for faster, clearer biotherapeutic insight in development today
Spot the winner in a crowded sky: Automated native MS for rapid hit discovery
Learn about multispecific antibodies and the use of 2D LC-MS for improved production and analysis.
Paucimannose isn’t just metabolic noise. Learn how glycan profiling in immune cells and cancer tissue reveals hidden layers of disease biology.
Automated workflows for analyzing antibody-drug conjugates, from fractionation and digestion to high-sensitivity nanoflow LC-MS/MS.

Japanese Resources

本セミナーでは、アジレントテクノロジーとプロテインメトリックスにおける、核酸医薬品LC,LCMS分析の最新ソリューションについてお話しします
タンパク質マトリックス MAM 分析プラットフォーム「Byos」および「Byosphere」をご覧ください。ライブデモやQ&Aも予定されています。

Get started with Protein Metrics