Byos Protein Characterization Software

Byos desktop software offers comprehensive mass spectrometry analysis workflows providing robust biotherapeutic protein characterization and reporting

Characterize Complex Biopharmaceutical Candidates

Byos is a vendor-neutral application that excels at taking raw mass spectrometry data and providing analysis, inspection and reports in minutes

Vendor Neutral Software Built for Scientists

Intuitive instrument agnostic protein characterization software allows you to process and directly compare mass spec data from different spectrometers.

A clean, clear user interface provides access to all the tools and data needed for rapid, confident protein analysis, and offers the most accurate analysis, quantifying species down to trace amounts.

Comprehensive Analysis and Reporting

Fast, thorough analytical workflows fully automate the mass spec analysis pipeline enabling any type of user to quickly analyze and characterize the most complex biopharmaceutical candidates.

Ensure consistency with templated reporting and unique algorithms that minimize ambiguity, achieve reproducibility, and eliminate lab-to-lab variability.

Future Proof Your Protein Analysis

Protein Metrics supports protein characterization across the entire product development process.

Add Byos capabilities depending on your research priorities or upgrade to Byosphere for enterprise level analysis, reporting and collaboration.

Launch Protein Characterization Workflows With One Click

Each workflow slashes the time involved in mass spectrometry analysis and reporting and ensures consistent reports across a group by automatically populating reports and summaries of analysis from templates.

Intact, Sub-Unit and Native Analysis

The Intact Mass workflow provides automatic MS/MS spectral annotation, MS level deconvolution, and identification, decreasing the time required for data analysis over traditional bottom-up approaches.

Peptide-Level Analysis

Dramatically reduce analysis time for peptide centric workflows with an integrated workflow, including sample preparation, peptide identification, data processing, and reporting.

Chromatogram Analysis

Streamline chromatogram analysis with tools including peak annotation, chromatogram alignment, peak and trace comparison, released glycan analysis, and automated report generation.

Multi-Protein Quantitation Analysis

Automate analysis for faster cell line selection, curated HCP quantitation, and instant protein mixture results. Templated dashboards simplify complex LC-MS/MS data, delivering clear insights to non-experts globally, in real time.

All Byos Workflows

Intact, Sub-unit, and Native Analysis

  • Ligand binding
  • Protein-protein interaction
  • Protein and subunit ID
  • Glyco-profiling
  • ADC and DAR analysis
  • Charge Variants by iCIEF-MS and CE-MS

Learn more about intact analysis >

Peptide-level Analysis

  • Hotspot analysis
  • Peptide mapping
  • PTM analysis
  • HCP analysis
  • Sequence variant analysis
  • Epitope mapping

Learn more about peptide analysis >

Multi-Protein Quantitation

  • Label-free, relative quantification of complex proteins
  • Proteome profiling and full protein characterization
  • Rapid sample prep and MS quality check

Learn more about multi-protein quantitation >

Oligos

  • Oligonucleotide workflows
  • Impurities and clips
  • Sequence confirmation for known oligos

Learn more about oligos >

De Novo Sequencing

  • Hands-free, automated sequencing of purified monoclonal antibodies

Learn more about de novo sequencing >

Chromatogram

  • MAM workflows
  • CE-UV data; SEC-UV, LC-UV & other chromatographic workflows
  • Import of 2D trace data

Learn more about chromatogram analysis >

Higher Order Structure

  • HDX and FPOP workflows
  • Epitope mapping, paratope mapping, other higher order structure work
  • Representation in .pdb format

Learn more about Higher Order Structure >

Intact Reconstruction

  • Correlate deconvoluted intact data with peptide mapping data
  • PTM quantification, degradation or conjugation analyses
  • Determine if acquisition parameters require optimization

Learn more about intact reconstruction >

MOBILion HRIM

  • Workflows for Mobie
  • Released Glycan, Intact and Peptide mapping workflows

Learn more about MOBILion HRIM >

icIEF MS

  • Intabio iCIEF workflows
  • Representation on a pI axis with deconvolution

Explore Byos

Videos & Guides

Explore our educational resources to advance your knowledge of Byos and all related workflows

Webinars

Register for upcoming webinars and events or watch on-demand recordings

Knowledge Base

Visit the knowledge base to read frequently asked questions and articles on getting the most out of Byos

Get started with Protein Metrics