Oligonucleotide Analysis

Perform high throughput oligo analysis to characterize sequences, determine molecular weight, identify and quantify impurities, and analyze digested nucleotides

Instantly Determine Molecular Weight and Sequence

Get fast and precise molecular weight measurements for all your oligonucleotide samples. The software effortlessly processes mass spectrometry data to deliver accurate results for intact samples. Built in top-down sequencing capability automatically renders MS2 spectra for sequence confirmation.

Characterize any Sequence

Unlock the secrets of your oligonucleotides with in-depth sequence characterization. The software uses MS/MS data to confirm the sequence of full length products and impurities. Internal fragments are also identified and labeled.

Identify and Quantify Impurities

Ensure the quality of your oligonucleotide samples with comprehensive impurity profiling. The software's unique "clipping" feature detects truncations and additions at both ends of the sequence for complete impurity analysis.

Generate Custom Reports

Gain tailored insights from your data. Create detailed reports, including relative intensity percentages, to understand the abundance of expected oligonucleotides and clipped species. Visualize key results clearly with individual bar charts for easy interpretation and impactful presentations.

Analyze Digested Oligonucleotides

Explore alternative experimental approaches with a dedicated digested oligonucleotide workflow. The software supports samples prepared with different RNAse enzymes for maximum versatility.

Handle any Modification

Specify and search for a wide range of modifications in your samples. The digested oligonucleotide workflow supports fixed modifications (e.g. those introduced by RNAse digestion) and variable modifications (e.g. methylated bases and 5' caps).

Automate Complex Analyses

Spend less time processing data and more time analyzing results. The intuitive oligo workflows automate oligonucleotide data processing, simplifying analyses and ensuring accuracy.

Explore Workflows

Intact Analysis

Automatic MS/MS spectral annotation, MS level deconvolution, and identification

Multi-Protein Quantitation

Faster cell line selection, curated HCP quantitation, and instant protein mixture results

Chromatograms

Align and compare multiple peptide maps to an annotated reference map

Peptide-Level Analysis

Identification of proteins and modified peptides in complex samples

Recommended Resources

Explore advanced workflows for oligonucleotide analysis, focusing on fragmentation and MS2 annotation.
Learn how to automate oligonucleotide data processing, handle raw files, define sequences, and generate custom reports.
Learn Byos Digested Oligonucleotide workflows, modification setup, investigation tools, and custom report creation.
Improve your organization’s efficiency and capability with automated LCMS analysis of synthetic oligos.

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