Research Spotlight on De Novo
This video series covers research on advanced mass spectrometry techniques for accurate antibody and protein structure analysis.
Series Content
De novo Sequencing
INSIDE THE VIDEO
Xinbi Li from Dragonfly explains using de novo sequencing with Protein Metrics to recover antibody clones in-house, saving time and costs with efficient control.
LENGTH
7 mins
Mass Spectrometry-Based De Novo
INSIDE THE VIDEO
Joost Snyder from Utrecht University developed a multi-protease protocol with Byos for complete antibody sequencing, advancing applications in antibody reverse engineering.
LENGTH
6 mins
Learn More
Byos General
Knowledge Base general articles for using Byos
Inspecting De Novo Sequencing (Supernovo) Results
Knowledge Base article that looks at de novo sequencing (Supernovo) results
Alternative Byonic Parameter Files for Byos De Novo Sequencing
Knowledge Base article for de novo sequencing
Reporting Basics
Knowledge Base article on reporting basics in Byos
More Resources
GUIDEQuick Guide to De Novo Sequence Analysis
An easy guide to getting started with de novo sequence analysis workflows.
VIDEO SERIESUsing Byonic
The Byonic tutorials explain MS/MS integration, peptide searches, charge adjustments, filtering PSMs, and report generation.
VIDEO SERIESUsing Byosphere
Byosphere enhances LC-MS analysis with custom searches, dashboards, automated workflows, audit trails, and project management.
PUBLICATIONAutomated Antibody De Novo Sequencing and Its Utility in Biopharma Discovery
A novel method to automatically de novo sequence antibodies using mass spec and Byos, and a demonstration of algorithm robustness.