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42:39
Automated de novo mAb Sequencing for a Modern Biotech

Using the right practical tools, de novo sequencing now can be easily turned into an in-house, higher throughput procedure with extremely high confidence.
1:00:51
PTM Analysis – How to Marry Speed and Confidence in R&D

John Reed covers the ins and outs of PTM analysis. He touches on peptide identification and the use of standard curves and weighted averaging of XICs - and a little bit of ice cream.
24:47
Native MS and Cell Line Development

With increasing complexity and volume of biotherapeutics, Janssen describe how they are implementing Byosphere to bring clarity to manage their workflows and deliver concise information when and where its needed.
51:08
Oligo Analysis Simplified: Get Your Answers Faster with Microchip CE-MS

The method utilizes ZipChip, a microfluidic capillary zone electrophoresis-based separation coupled with HRAM mass-spectrometry (CE-MS) for rapid characterization of oligos in positive ionization mode.

4:20
Chemical probing provides insight into the native assembly state of a bacterial microcompartment

Bacterial microcompartments (BMCs) are widespread in bacteria and are used for a variety of metabolic purposes -authors used cross-linking probes to unravel the native assembly states of these large complexes.

33:28
質量分析によるオリゴヌクレオチド分析：配列の表示および自動化はもはやシーシュポスの作業（果てしない徒労）ではない

For fast ranking during expression vector design and clone selection, Lonza's setup for high throughput intact MS uses Protein Metric’s parsimonious charge deconvolution algorithm.
7:53
Proteomic Analysis of Adenovirus 5 by UHPLC-MS/MS: Development of a Robust and Reproducible Sample Preparation Workflow

The novel workflow for AdV VP analysis affords substantially lower analysis times than traditional peptide mapping methods, which require the use of several proteases and long sample processing for sufficient in-depth characterization.

20:31
EU UGM 2023: Friends with benefits: Glycoproteomics meets Chemical Biology

A glycoproteomics platform comprising custom chemical probes and time resolved proteolysis of biogicals.
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