This webinar presents an in-depth look into the advanced method of X-ray hydroxyl Radical Footprinting as a tool for structural analysis of proteins in solution. Corey Ralston, a staff scientist at Lawrence Berkeley National Lab at the Molecular Foundry, introduces this innovative method which utilizes X-rays to generate modifications on proteins. The talk details the process and benefits of this technique, further supported by Lena Christensen’s insights on utilizing protein metric software for analyzing these modifications.

We delve into the historical context and development of hydroxyl Radical Footprinting, exploring its evolution from DNA binding studies to its current applications in studying protein structure and interactions. The method’s ability to provide rapid and detailed structural information makes it a pivotal tool in biochemistry. The webinar not only highlights technical details and procedural advancements but also emphasizes real-world applications, demonstrating the method’s effectiveness in various research scenarios. Join us as we explore how X-ray hydroxyl Radical Footprinting, combined with sophisticated software analysis, is revolutionizing our approach to understanding protein dynamics and interactions.