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Featured Resources
7:23
Unexpected Modifications in Cell-Line Characterization

Harsha Gunawardena at Johnson & Johnson talks us through how they handle these analytically challenging situations.

5:34
MS-Based De Novo Sequencing of mAbs Using Multiple Proteases and a Dual Fragmentation Scheme

By using multiple proteases and dual fragmentation the authors are able to get the most accurate sequences and the best depth of coverage whilst optimizing protocols for de novo antibody sequencing

17:24
Database Search of Tandem Mass Spectrometry of Oligonucleotides

In collaboration with the University of Texas at Austin, Rose discusses MS1 and MS2 analysis of oligonucleotides and the application of Byonic proteomics features for these molecules
1:00:51
PTM Analysis – How to Marry Speed and Confidence in R&D

John Reed covers the ins and outs of PTM analysis. He touches on peptide identification and the use of standard curves and weighted averaging of XICs - and a little bit of ice cream.
47:05
Analytical Characterization of Oligonucleotides by LC-HRMS and BYOS

Joint presentation with Phenomenex, we show novel automatic identification of process-related impurities using high-resolution MS (HRMS), new LC columns for oligo analysis, and novel deconvolution / mass-matching software.
7:53
Proteomic Analysis of Adenovirus 5 by UHPLC-MS/MS: Development of a Robust and Reproducible Sample Preparation Workflow

The novel workflow for AdV VP analysis affords substantially lower analysis times than traditional peptide mapping methods, which require the use of several proteases and long sample processing for sufficient in-depth characterization.

33:27
EU UGM 2023: Enhancing the Dimensionality of Glycoproteomics

Can sample pretreatment hide biologically important glycan species? Can Ion mobility be used to boost glycopeptide detction?
23:18
EU UGM 2023: Protein Metrics’ MAM application as a robust standard for PTM detection in large scale forced degradation studies

Creating robust standards and high throughput method development for large scale forced degradation studies and PTM reporting
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