Request demo
Automation Antibody Drug Conjugates Byosphere Charge Variant Analysis Higher Order Structure High Throughput Intact Released Glycan
  • Automation
  • Antibody Drug Conjugates
  • Byosphere
  • Charge Variant Analysis
  • Higher Order Structure
  • High Throughput
  • Intact
  • Released Glycan
Lab of the Future - Fully Automated High Throughput Mass Spectrometry for Biotherapeutics

Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics, as implemented at Janssen.
ASMS 2023: Orthogonal techniques for LCMS characterization of a lysine-conjugated ADC

Lysine-based conjugation is a widely used non-specific conjugation strategy for the development of Antibody Drug Conjugates (ADCs). Conjugation at lysine residues results in highly heterogeneous products that pose challenges to current characterization methods.
ASMS 2023: Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS

The Byos platform Intact workflow offers efficient identification, inspection, and relative quantification of charge variants, while reliably detecting even the low abundance species and highlighting even subtle differences between innovator and biosimilar products.

 Lab of the Future - Fully Automated High Throughput Mass Spectrometry for Biotherapeutics

Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics, as implemented at Janssen.
ASMS 2023: Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS

The Byos platform Intact workflow offers efficient identification, inspection, and relative quantification of charge variants, while reliably detecting even the low abundance species and highlighting even subtle differences between innovator and biosimilar products.
Histidine hydrogen-deuterium exchange (His-HDX) mass spectrometry for identifying protein-ligand interactions

The Byos HDX workflow makes it easy to analyze complex deuterium ratio calculations and visualize the results, helping to reduce analysis time

 ASMS 2023: Investigations of a Bispecific Antibody Dimerization via Hydroxyl Radical Footprinting

Authors report how PLIMB can be used to understand potential mechanism for bsAb aggregate formation using a tool molecule from clarified culture harvest
ASMS 2023: A Real-time Informatics Pipeline Enables Screening of Biologics during High-Throughput Expression

Raw MS data and associated meta data are swept to an automation module in Byosphere that resides in the J&J cloud server.
Advanced querying capabilities and quality control of data allows triaging voluminous data sets

 Lab of the Future - Fully Automated High Throughput Mass Spectrometry for Biotherapeutics

Here we describe a state-of-the-art, integrated, multi-instrument automated system designed to execute methods involved in mass spectrometry characterization of biotherapeutics, as implemented at Janssen.
ASMS 2023: Coupling online buffer exchange with automated data processing for screening designed protein complexes by native mass spectrometry

Combining OBE nMS with PMI software enables rapid analysis of masses, binding partners, and stoichiometries of designed protein assemblies

 ASMS 2023: Effects of Fab glycosylation on anti - SARS - CoV - 2 antibody - antigen binding assessed by SEC and LC - MS

Study of anti-spike protein (SARS-CoV-2) blocking mAbs with a focus on measuring Fab glycosylation and its impact on binding to spike protein antigens
ASMS 2023: Automated Spectrum Annotation and Structure Disambiguation of Released N-linked Glycans

Monosaccharide composition is often discernible directly from accurate molecular mass (MS1); however, topology (monosaccharide connectivity) requires MS2, and glycosidic linkage information and anomericity requires, at least, MS3 if not combined with orthogonal insight.1 Here we report on disambiguation of topological isomers directly from tandem MS spectra