Bovine milk immunoglobulin G: NeuAc to NeuGc

This webinar covers the key changes in bovine milk immunoglobulin G during lactation, emphasizing the hallmark NeuAc sialylation of colostrum immunoglobulin G N-glycosylation. Dr. Inge Gazi, a postdoctoral researcher at the University of Utrecht and associate editor of the International Dairy Journal, delves into her extensive research on dairy science. Using a glycoproteomics approach, the webinar investigates the lactational differences in the N-glycosylation of bovine immunoglobulin G, revealing a broad repertoire of glycoforms with notable dynamics between colostrum and mature milk. This includes the interplay between NeuAc and NeuGc sialylation, providing insights into the transfer of passive immunity between cow and calf, and potential impacts on human nutrition.

Furthermore, the session provides an overview of the tools and methodologies used in this research, with Byonic, a search engine utilized for identifying peptides and glycopeptides. Attendees gain a comprehensive understanding of the advancements in bovine milk immunoglobulin G, the significance of its N-glycosylation, and the practical applications of these findings in both the dairy industry and nutritional science.