Resources

Explore our educational resources to advance your knowledge of Protein Metrics

Intact Mass

An easy guide to getting started with intact, reduced, ADC, intact reconstruction, and IntaBio icIEF-MS workflows.
Run intact mass workflows in Byos. Manage data, sequences, masses, deconvolution, and generate reports for ADCs, glycosylation, and oligos.
Watch this video on a novel serum stability assay, enhancing accuracy in biologics screening with in vitro methods.
Learn about multispecific antibodies and the use of 2D LC-MS for improved production and analysis.
Discover how automating high-throughput LC-MS revolutionizes biotherapeutic discovery with faster QC and molecule diversity.
Bottom-up methods like peptide mapping can be used to build reconstructions of both theoretical intact mass spectra and theoretical electropherograms.

Oligonucleotides

Learn how to get started with oligonucleotide analysis, including digested oligonucleotide analysis.
Learn how to automate oligonucleotide data processing, handle raw files, define sequences, and generate custom reports.
Learn Byos Digested Oligonucleotide workflows, modification setup, investigation tools, and custom report creation.
Explore advanced workflows for oligonucleotide analysis, focusing on fragmentation and MS2 annotation.

Multi-Protein Quantitation

An easy guide to getting started with multi-protein quantitation, multi-protein identification, and multi-protein preview workflows.
Read posters about our new Multi-Protein Quantitation workflow and other cutting-edge mass spec advancements and biopharmaceutical innovations.

Peptide

Getting started with HCP, HotSpot, PTM, SVA, S-S, MAM new peak detection, system suitability, and oxidative footprinting workflows.
Explore peptide workflows, set up searches, interpret scores, validate peptides, manage disulfide mapping, and create reports.
Learn how to manage disulfide workflows, add samples, define sequences, create disulfide bridge and validate linked peptides.
Watch these spotlight videos on peptides covering methods for mapping, quantitation, glycosylation, and antibody stability.
Watch these spotlight videos on rapid cross-link detection, bacterial microcompartment assembly, and bond stability in proteins.
Watch these spotlight videos on glycosylation analysis techniques, covering protein glycan structures and SARS-CoV-2 applications.
A state-of-the-art, integrated, multi-instrument automated system for MS characterization of biotherapeutics.

Chromatogram

An easy guide to getting started with chromatography workflows, including reference, characterization and in-silico chromatography.
Learn to use chromatogram workflows for peak analysis, adjust baselines, integrate peaks, align traces, and explore glycan analysis.
Learn to use released glycan workflows for N-glycans, O-glycans, and IGG glycans. Explore Glycan cartoons for visual representation.
Getting started with released glycan (N-linked), released glycan (O-linked), and released glycan (IgG) workflows.
Compare biosimilar and innovator glycan analysis to understand therapeutic efficacy and patient outcomes.

Reconstruction

Follow this short guide and learn how to get started with change variant analysis with reconstruction.
Perform intact reconstruction and charge variant analysis. Set up projects, configure processing nodes, and align CIEF traces effectively.
The latest in multispecifics with videos on bispecific antibody stability, mispairing, and effective characterization methods.
Learn about multispecific antibodies and the use of 2D LC-MS for improved production and analysis.

Higher Order Structure

An easy guide to getting started with HDX analysis, including all our HDX workflows.
The HDX tutorial series explains how to set up HDX workflows, analyze deuterium uptake, and generate detailed protein reports.
Explore higher-order structure in these videos on plasma-induced modification and bacterial microcompartment assembly insights.
Dive into HDX MS analysis of SARS-CoV-2 spike protein, focusing on glycopeptide inclusion and its challenges.

Other Workflows

Follow this short guide and learn how to get started with MOBILion High-Resolution Ion Mobility (HRIM) analysis.
An easy guide to getting started with de novo sequence analysis workflows.
This video series covers research on advanced mass spectrometry techniques for accurate antibody and protein structure analysis.
A novel method to automatically de novo sequence antibodies using mass spec and Byos, and a demonstration of algorithm robustness.

Byonic

The Byonic tutorials explain MS/MS integration, peptide searches, charge adjustments, filtering PSMs, and report generation.
Dive into HDX MS analysis of SARS-CoV-2 spike protein, focusing on glycopeptide inclusion and its challenges.
Investigating the lactational differences in the N-glycosylation of bovine IgG and an overview of tools and methods including Byonic.
Byonic is a new software package for peptide and protein identification by tandem mass spectrometry, facilitating a wide range of search possibilities
Improvements to Byonic, a glycoproteomics search program, that addresses the analytical and bioinformatics challenges glycopeptide analysis poses.

Byosphere

Byosphere enhances LC-MS analysis with custom searches, dashboards, automated workflows, audit trails, and project management.
CSL explore uses of Byosphere in characterizing polyclonal IgG products focusing on plasma product development.
Heather Oakes discusses Lonza's CDMO mass spectrometry approach, focusing on flexibility for diverse molecules.
Use dashboards and deep query tools to analyze data, spot outliers, and enhance lab collaboration globally.

Japanese Resources

LC-MS, icIEF-UV/MSを用いたチャージバリアント、糖鎖を含む詳細な修飾解析
本セミナーでは、アジレントテクノロジーとプロテインメトリックスにおける、核酸医薬品LC,LCMS分析の最新ソリューションについてお話しします
タンパク質マトリックス MAM 分析プラットフォーム「Byos」および「Byosphere」をご覧ください。ライブデモやQ&Aも予定されています。

Video Tutorials

Run intact mass workflows in Byos. Manage data, sequences, masses, deconvolution, and generate reports for ADCs, glycosylation, and oligos.
Explore peptide workflows, set up searches, interpret scores, validate peptides, manage disulfide mapping, and create reports.
Learn to use chromatogram workflows for peak analysis, adjust baselines, integrate peaks, align traces, and explore glycan analysis.
Learn to use released glycan workflows for N-glycans, O-glycans, and IGG glycans. Explore Glycan cartoons for visual representation.
Learn how to automate oligonucleotide data processing, handle raw files, define sequences, and generate custom reports.
Learn Byos Digested Oligonucleotide workflows, modification setup, investigation tools, and custom report creation.
Perform intact reconstruction and charge variant analysis. Set up projects, configure processing nodes, and align CIEF traces effectively.
Learn how to manage disulfide workflows, add samples, define sequences, create disulfide bridge and validate linked peptides.
The HDX tutorial series explains how to set up HDX workflows, analyze deuterium uptake, and generate detailed protein reports.
Byosphere enhances LC-MS analysis with custom searches, dashboards, automated workflows, audit trails, and project management.
The Byonic tutorials explain MS/MS integration, peptide searches, charge adjustments, filtering PSMs, and report generation.

Get started with Protein Metrics