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42:39
Automated de novo mAb Sequencing for a Modern Biotech

Using the right practical tools, de novo sequencing now can be easily turned into an in-house, higher throughput procedure with extremely high confidence.
3:03
Orthogonal Comparison of Analytical Methods by Intact Reconstruction

By using bottom-up data to build a theoretical reconstruction of the intact data and then juxtaposing it with the experimental intact data, differences and similarities between the two orthogonal methods can quickly be qualitatively determined.

5:34
MS-Based De Novo Sequencing of mAbs Using Multiple Proteases and a Dual Fragmentation Scheme

By using multiple proteases and dual fragmentation the authors are able to get the most accurate sequences and the best depth of coverage whilst optimizing protocols for de novo antibody sequencing

6:39
Dragonfly Therapeutics – De Novo Sequencing

By taking de novo sequencing in house, Dragonfly have improved their turn around time, throughput, their depth of information on their mAbs as well as showing impressive cost savings

47:05
Analytical Characterization of Oligonucleotides by LC-HRMS and BYOS

Joint presentation with Phenomenex, we show novel automatic identification of process-related impurities using high-resolution MS (HRMS), new LC columns for oligo analysis, and novel deconvolution / mass-matching software.
54:45
EPO: Separation and Analysis

EPO has also been historically very difficult to characterize by traditional approaches. Looking for a faster, simpler way of separating and analyzing?
30:46
Development of a HILIC method for detection of low abundant N-glyco-peptides

Florian Krattenmacher describes the thought process in the development and validation of methods for the detection of low abundance glycopeptides
34:46
High throughput screening and data analysis using Native Mass Spectrometry and Byos

Under carefully optimized instrumental conditions it is feasible to quantify the drug dissociation constant (Kd). OMass Therapeutics presents in house high-throughput native MS screening platform combined with high-throughput data processing.
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