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18:47
Three Channel Charge Deconvolution

There are two quite different methods for determining the charge of m/z peaks:  peak spacing for isotope-resolved masses, and ratio relations among peaks for isotope-unresolved masses. Most software uses one method or the other, but Protein Metrics Intact Mass can use both information channels simultaneously, as well as a third channel...
1:01:35
Real Time Monitoring of Bioprocess & Beyond – A Process Analytical Perspective

Presented by Bristol Meyers Squibb and Protein Metrics. A roadmap for successful implementation of PAT tools - identification of critical quality attributes and critical control points of the bioprocess for efficient and smarter development.

43:00
Harnessing Novel MS Approaches (MAM, IEX-MS) to Accelerate Biotherapeutic Development and Analysis

MAM workflows are implemented differently according to the vagaries of your organisation. Ben Niu speaks to the Astra implementation across product and process characterization to optimise throughput whilst respecting robustness and variability .
48:58
Driving Efficiency in Pre-Clinical Development with Automated Mass-Spectrometry Analysis

The cell and developability sciences group is tasked with delivering lead manufacturing cell lines. Not only are the volume of request increasing, but so are the novelty and complexity of new molecules to characterize.

18:23
The Sweet Science of Sparkling Wine

Glycoproteins have been linked to positive and negative qualities in sparkling wine, but the glycosylation profiles of sparkling wine have not been previously investigated in detail. Hear from Dr Pegg on how she has been addressing the glycoproteome analysis of sparkling wine.
33:32
Characterizing the glycan shield of the Hepatitis C E1E2 glycoprotein complex using mass spectrometry

Maddy Newby takes us through the steps for unravelling the structural details of the E1E2 glycoprotein complex whilst also uncovering a novel glycan site within a non-canonical N-linked glycan site.

5:37
Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

A panel of stress conditions ( including temperature, pH, oxidizing agents, and forced glycation) were applied to identify and functionally evaluate critical quality attributes in the complementary-determining and conserved regions of a bispecific antibody was applied in this study.
37:52
EU UGM 2023: Annotation of topdown mass spectra of proteins and oligonucleotides

The latest on our Oligo workflows including long digested oligonucleotides - especially mRNAs
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