Accelerating Multi-Attribute Methods (MAM) – Automating Workflows from Sample Prep to Data Analysis with Vendor-Neutral Software

Multi-Attribute Monitoring (MAM) in Byos® Part A – CQA Identification (和訳版)

Multi-Attribute Monitoring (MAM) in Byos® Part B – New Peak Detection & CQA Quantification (和訳版)

Validation of Fully Automated Sample Prep Protocol for Peptide Multiple-Attribute Monitoring (MAM) using Quantitative Peptide Analysis

Byos Disulfide Bond Analysis (和訳版)

In-silico Disulfides CSV (和訳版)

How Janssen, Genentech, and Amgen Create a Highly Automated Analysis of Antibody Chain Shuffling in Bispecific Antibodies

Rapid Identification and Quantitation of Disulfide Bonds in Infliximab – Remicade vs Remsima

How to Analyze Biosimilars with Confidence (中译版)

Byos® Sequence Variant Analysis (SVA) (中译版)

Automating Sequence Variant and Post-Translational Modification Analysis (中译版)

Informative Protein Charge Variant Analysis by Native Spray Mass Spectrometry

Detached Glycan Analysis in Byos®

Automating Data Processing for Glycan and Peptide Mapping: Leveraging Byos® to Improve Efficiency and Quality

Glyco-Analysis: Byonic™: N-Linked Glycopeptide Analysis (和訳版)

Glyco-Analysis: Byonic™: O-Linked Glycopeptide Analysis (和訳版)

Specific and Confident Glycation Site Mapping in Therapeutic Proteins Using Automated Data Processing

Byonic™: Modification Fine Control™

Byonic™: Wildcard Search™

Byonic™: Mass Tolerance Settings

Crosslink Searches in Byonic

Byonic™: Focused Protein Databases

Integrated software platform for analyzing hydrogen-deuterium exchange data for solvent accessibility of the Marburg filoviral protein (2021)

HCP Analysis: Host Cell Protein (HCP) Analysis in Byos®

Drug-to-antibody ratio quantification using native SECMS analysis of antibody–drug conjugates

Evaluation of a New Software Tool for Assisting with the siRNA Metabolite Identification by LC/MS

Asparagine Deamidation Quantified by Byos® (和訳版)

Automated Data Filtering for Rapid Sample Comparison of Human milk Glycoproteins

Characterization of Adeno-Associated Virus Capsid Proteins Using Hydrophilic Interaction Chromatography Coupled with Mass Spectrometry Using Byos®

Chromatogram labeling with CSVs

Intact and Chromatography Trace Peak Settings

AAV Characterization: Direct Bottom-up versus Intact MS analysis Comparison (中译版)

Intact Profiling and Visualization of Urinary Prostate-Specific Antigen (PSA) Profiles from Pooled and Individual Patient Samples

Coagulation factor IX analysis in bioreactor cell culture supernatant

Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Highly Automated Analysis of Chain Shuffling in Bispecific Antibodies

Rapid Protein Characterization by the ZipChip-MS Platform

How to Maintain Data Quality across Time and Mass Spectrometry Platforms

Comparability and Biosimilarity Assessment with Protein Metrics

Released Glycan Analysis in Byos® and Using Cartoons

Byosphere™ Enterprise Platform: Bringing Speed and Depth to Protein Mass Spec Analysis

Byosphere® Enterprise Platform: Manage LC-UV-MS Data Seamlessly with Byosphere®

Intact Reconstruction of a Lysine Conjugated ADC from Quantitative Peptide Mapping Data, Generated Using an Arginine-specific Protease

Sciex – Characterization of a multi-specific antibody therapeutic with peptide mapping

Optimization of a Label-Free Peptide Quantitation Strategy for Analysis of Therapeutic Proteins: Insights from Roche’s Assessment and Byos Implementation

Intact Mass: Workflow Setup for Low MW (<10 kDa) Isotopically Resolved Peptides

Intact Analysis of a Purified Therapeutic Protein Incorporating Top-Down Fragmentation

Byosphere: Introduction

Byosphere: Getting Started

Byosphere: Custom Metadata Fields

Byosphere: Dashboards

Byosphere: Advanced Queries

Byosphere: Intact Web Analysis

Byosphere: GxP Compliance

Byosphere: Audit Trails

Byosphere: Auto Scaling

Byonic: Byonic Introduction

Byonic: Preview Overview

Byonic: Modification Fine Control

Byonic: Advanced Tab

Intact Mass: Workflows Overview

Intact Mass: Adding data and peak integration options

Intact Mass: Adding sequences

Intact Mass: Delta Mass

Intact Mass: Deconvolution settings

Intact Mass: GUI

Intact Mass: Using .csv workflows

Intact Mass: Reports Overview

Intact Mass: ADC Workflow

Intact: Advanced Commands

Intact Mass: Oligonucleotides

Peptide: Workflows Overview

Peptide: Creating Projects, Samples and Proteins Tabs

Peptide: Processing Nodes: Byonic Intro

Peptide: Processing Nodes: Byonic Details

Peptide: Byonic Results

Peptide: Processing Nodes: Byologic Options

Peptide: GUI, Overview, Validation, Comments, Labels

Peptide: Deamidation

Peptide: Report Overview

Peptide: Peptide Manager Explained

Peptide: Glycan Cartoon

Peptide: Advanced Commands

Peptide: IsoAsp

Peptide: disulfides

Chromatogram: Workflows Overview

Chromatogram: Integration Set Up

Chromatogram: Creating a MS2 Reference Project

Chromatogram: Creating an in-silico Reference Project

Chromatogram: Creating a Comparison Project

Chromatogram: Baseline Anchors

Chromatogram: Released Glycans Introduction

Chromatogram: Released Glycans Project Creation

Chromatogram: GUI & Project Interface

Byos Reporting Basics

Disulfide Bonding in Byos

Ligand Binding with High Res Native MS

Data Visualization for HCPs

Unanticipated N- and O- Glycopeptides

Byos Multi Step Searches

HDX: Introduction

HDX: Reports

HDX: Inspection View

Byonic: Byonic Only workflow in Byos

Byonic: Preview in Byosphere

Reconstruction: Intact Reconstruction

Chromatogram: Processing Biophysical (non-MS) data

new Digested Oligos: Introduction

new Digested Oligos: Workflow Set Up

new Digested Oligos: Modifications

new Digested Oligos: Investigation View

new Digested Oligos: Customizing Layout

new Digested Oligos: Reporting

new Digested Oligos: Table View

Reconstruction: Charge Variant Reconstruction

アジレント、プロテインメトリックスが提供する医薬品オリゴ核酸分析の課題と解決法

Reconstructing cIEF Profiles Using Peptide Mapping Data

効率的なMAM解析

NA_UGM24: Dashboards and Deep Query

Bovine milk immunoglobulin G: NeuAc to NeuGc

NA_UGM24: State of the Union

NA_UGM24: Navigating the Future of Laboratory Automation

NA_UGM24: Intact Mass Characterization of Multispecific Therapeutic Antibodies

NA_UGM24: How Protein Metrics Saved Me From Carpel Tunnel

NA_UGM24: A 3 body problem: Automation, Integration & Human

NA_UGM24: Automating QC In Discovery Therapeutics : Leveraging Byosphere to Maximize Potential in High Throughput Intact MS QC

NA_UGM24: Robust automated quantitation with improved feature detection, peak bounding, and cross-sample feature association

NA_UGM24: MS analysis of intact oligonucleotides

NA_UGM24: Panel Discussion – Gearing Up For Smarter Workflows

Unraveling the Twin Tales of Biosimilar and Innovator Glycans

Increasing Analytical Efficiency at a CDMO

From Here to Byosphere

HDX-MS analysis of SARS-CoV-2 spike ectodomain

Spotting the Outliers and New Peaks in MAM Runs Automatically

JUGM 2023: 生体試料中のADCのDAR推移の分析におけるBYOSの活用例

JUGM 2023: 製品ロードマップ

JUGM 2023: 目からうろこByos/Byonicの成り立ちから有効活用のtipsまで

JUGM 2023: タンパク質特性解析のデジタル化

JUGM 2023: ByosがMulti-Attribute Method(MAM)に貢献できること

JUGM 2023: Byosphereご紹介

JUGM 2023: ヒスチジン水素重水素交換質量分析法による生体内タンパク質・リガンドの網羅的な結合評価への挑戦

Resolving Antibody Aggregation During Discovery & Development

EU UGM 2023: Impurity Characterisation of modified siRNA using Byos Oligo Workflow

EU UGM 2023: Enhancing the Dimensionality of Glycoproteomics

EU UGM 2023: Protein Metrics’ MAM application as a robust standard for PTM detection in large scale forced degradation studies

EU UGM 2023: The Growing Importance and Changing Needs for Data Analysis & Informatics – US UGM

EU UGM 2023: Annotation of topdown mass spectra of proteins and oligonucleotides

EU UGM 2023: Bispecific Antibody Formats – Challenges in Peptide Mapping and how a Multi Enzyme Approach improves the Analysis of Sequence Variants

EU UGM 2023: Byosphere assisted biopharmaceutical development

EU UGM 2023: Friends with benefits: Glycoproteomics meets Chemical Biology

EU UGM 2023: Introduction & State of the Union

Neutrophil azurophilic granule glycoproteins – atypical glycans

Mass Spectrometry Techniques Enabling Accelerated Process and Product Development of Bispecific Antibodies (中译版)

WCBP 2023: Unearth the value of your complex biopharma data

Characterizing the glycan shield of the Hepatitis C E1E2 glycoprotein complex using mass spectrometry

Tackling the Glycan Isomer Challenge for your Biotherapeutics

質量分析によるオリゴヌクレオチド分析：配列の表示および自動化はもはやシーシュポスの作業（果てしない徒労）ではない

High throughput screening and data analysis using Native Mass Spectrometry and Byos

Monitoring System Suitability – Byosphere Dashboards (中译版)

PEGS 2022 – Mining Biological Attributes with Dashboards

2022 Bioprocessing Summit: Autonomous Pipeline for Characterizing Biotherapeutics

EU UGM 2022 – Importance of Data Analysis & Informatics in Development – Dashboards Latest

EU UGM 2022 – Introduction & State of the Union

EU UGM 2022 – Development of a HILIC method for detection of low abundant N-glyco-peptides

EU UGM 2022 – Structural Determinants Regulating Viral Spike Glycosylation and Biomolecular Interactions

EU UGM 2022 – Rapid Analysis of Oligonucleotides by High-Resolution Accurate Mass CE-MS

EU UGM 2022 – LC-MS and LC-MS/MS Analyses of Adeno-Associated Viruses Anc80

EU UGM 2022 – EPO analysis using ZIP Chip CE-MS and Byos Software

EU UGM 2022 – Addressing MS Data Bottlenecks and Biopharmaceutical Case Studies

Stanford SUMS Seminar – Connecting LC-MS data analysis with non-MS techniques

Intact Profiling and Visualization of Urinary Prostate-Specific Antigen Profiles

Generating Wisdom from Raw Data – The Post Genomic World

The Sweet Science of Sparkling Wine

Assigning function to the structure of HIV and SARS-CoV-2 glycan shields

Analytical Characterization of Oligonucleotides by LC-HRMS and BYOS

Three Channel Charge Deconvolution

Byosphere™ Enterprise Platform – Metadata & Dashboards

Harnessing Novel MS Approaches (MAM, IEX-MS) to Accelerate Biotherapeutic Development and Analysis

Bringing your analysis to the enterprise: Introducing Byosphere™

Ensuring Safety and Efficacy of Biotherapeutics Through In-Depth LC-MS Sequence Variant Analysis

EAD: Making characterization of complex biotherapeutics routine

EPO: Separation and Analysis

Oligo Analysis Simplified: Get Your Answers Faster with Microchip CE-MS

Bispecific MS Analysis and Cell Line Development

Recent Progress in MS-Based Workflows and Case Studies from a Biopharmaceutical Development Lab

Comprehensive Adeno-Associated Virus CQA Analysis with LC/MS

Biosimilar Characterization

Characterizing Next Generation Biotherapeutics with Novel Ion Trapping and Alternative Fragmentation

Implementing an Enterprise Solution for MAM with LC-UV-MS

Data Visualisation for Routine Host Cell Protein Analysis

Oligonucleotide Characterization Using the BYOS Intact Mass Workflow

Real Time Monitoring of Bioprocess & Beyond – A Process Analytical Perspective

Automated de novo mAb Sequencing for a Modern Biotech

All Tangled Up: High Resolution Neuroproteomics of the human p-Tau Interactome

Keeping it all together – Bacterial Cell Envelope Structure

Automated Feedback Control of Protein Characteristics in a Perfusion Bioprocess

Automating data collecting and analysis in the X-ray hydroxyl radical footprinting method

Rapid Intact Charge Variant Analysis with Coupled icIEF-MS

Analyzing the SARS Cov-2 Glycan Shield with Mass Spec

PTM Analysis – How to Marry Speed and Confidence in R&D

How to Advance Your Host Cell Protein Analysis with Mass Spectrometry

An Implementation of Vendor-Neutral Multi-Attribute Method (MAM)

Native MS and Cell Line Development

Driving Efficiency in Pre-Clinical Development with Automated Mass-Spectrometry Analysis

Zeta 2018: Why don’t we monitor drug product profile directly?

Improving Intact Antibody and Plasma Glycoprotein Analysis with Native MS and Parsimonious Charge Deconvolution

Streamlining PTM Workflows: From Sample Prep to Data Analysis

HT Analysis of Bispecific Antibody Moieties and Glycosylation

Model Based Algorithms for Intact Mass Analysis of Biotherapeutics

Large-scale Glycopeptide Identification by Database Search

ASMS 2024: Charge Variant Mass spectrometry for Analysis of biotherapeutics with Orthogonal and Fractionated sampling

ASMS 2024: Utilization of Intact Reconstruction to Characterize Bi-specific Antibodies (Video 3:03)

ASMS 2024: Assessment of different MS Label-Free Quantitation Strategies for Therapeutic Proteins

ASMS 2024: Network method for building a sample-specific glycan database for N-linked glycosylation from MS/MS data (中译版)

ASMS 2024: Determination of drug-to-antibody ratio of antibody-drug conjugate in biological samples using microflow-liquid chromatography/HRMS (中译版)

ASMS 2024: Optimization and Characterization of Disulfide Linkages in the Complex Cysteine Engineered Stapled scFv for Bispecific Antibodies (中译版)

ASMS 2024: Computer Modeling of the Effectiveness of MS1 and MS2 for mRNA Sequence Confirmation (中译版)

ASMS 2024: A Middle-Level Approach to Simplify Sample Preparation and Data Analysis for Characterization of the Fusion Protein Blinatumomab (中译版)

CASSS 2023: Optimization of a Liquid Chromatography-Tandem Mass Spectrometry mRNA Sequence Mapping Workflow (中译版)

Fragmentation-free characterization of glycopeptides with ion mobility

MSSJ 2023 – High-Sensitivity Charge Deconvolution Algorithm for Low-Abundance Biological Macromolecules

ASMS 2023: Orthogonal techniques for LCMS characterization of a lysine-conjugated ADC (和訳版) (中译版)

ASMS 2023: Histidine hydrogen-deuterium exchange (His-HDX) mass spectrometry for identifying protein-ligand interactions

ASMS 2023: Sample to Result Workflow for the Investigation of Biosimilars vs Innovator Cetuximab by Charge Variant Analysis using Microchip CE-MS

ASMS 2023: Automated Spectrum Annotation and Structure Disambiguation of Released N-linked Glycans

ASMS 2023: Coupling online buffer exchange with automated data processing for screening designed protein complexes by native mass spectrometry

ASMS 2023: A Real-time Informatics Pipeline Enables Screening of Biologics during High-Throughput Expression (中译版) (Video Poster 5:10)

ASMS 2023: Investigations of a Bispecific Antibody Dimerization via Hydroxyl Radical Footprinting

ASMS 2023: Effects of Fab glycosylation on anti – SARS – CoV – 2 antibody – antigen binding assessed by SEC and LC – MS

TIDES 2022 – A Microchip CE-MS Based End-to-End Solution for the Analysis of Synthetic Oligonucleotides

ASMS 2022 – High-throughput Monitoring of Biotherapeutic Critical Quality Attributes with High-Resolution Ion Mobility-Mass Spectrometry (HRIM-MS)

ASMS 2022 – High Throughput Automation Platform of Intact Mass Spectrometry Data to Support Cell Line Development (CLD) of Multi-specific Antibodies (和訳版)

ASMS 2022 – Tandem Mass Spectrometry Metrics for Reliable and Automated Assignment of Protonated Glycan Isomers

ASMS 2022 – Comprehensive site-specific glycan profiling of a protein-based flu vaccine using electron activated dissociation (EAD) (和訳版)

ASMS 2022 – Comprehensive characterization of complex linkage structures in a bispecific monoclonal antibody (mAb) using electron activated dissociation (EAD) (和訳版)

ASMS 2022 – Characterization of Isomeric O-Glycopeptides using µLC, Differential Mobility Spectrometry, Collision Induced and Electron Capture Dissociation

ASMS 2022 – Chromatography ‘super-resolution’: Improved HDX mapping using long gradients and time warping (和訳版)

ASMS 2022 – Native Mass Spectrometry and Fast Photochemical Oxidation of Proteins (FPOP) for Characterization of TREM2 interaction with Amyloid β1-42 peptide

ASMS 2022 – High-Sensitivity Charge Deconvolution Algorithm for Low-Abundance Biological Macromolecules (和訳版) (中文视频)

ASMS 2022 – LC-MS/MS proteomics reveals anticancer compounds from Lansium domesticum against NSCLC cells target mitochondrial processes

ASMS 2022 – Survival of infant formula N glycoproteins across simulated infant gastrointestinal digestion

ASMS 2022 – Epitope Mapping of HER2 with Single Amino Acid-Level Resolution using a Combination of Plasma-Initiated Radical Trifluoromethylation and Hydroxyl Radical Footprinting

ASMS 2022 – Capillary Electrophoresis Mass Spectrometry (CEMS) of Oligonucleotides using a 908Devices ZipChip

ASMS 2022 – Characterization of Biotherapeutics with High-Resolution Ion Mobility-Mass Spectrometry

Bottom-up and Top-down Disulfide Bond Mapping of Beta-lactoglobulin on a Q-TOF with the Capability to Perform both CID and ECD

ASMS 2022 – Chromatography ‘super-resolution’: Improved HDX mapping using long gradients and time warping (Video)

BMSS 2022: Oligonucleotide Analysis by Mass Spectrometry: Sequence Display and Automation is no longer a Sisyphean Task (和訳版)

BMSS 2022: High Sensitivity Charge Deconvolution Algorithm for Low Abundance Biological Macromolecules

CASSS 2022: Continuous Monitoring of System Suitability with Byosphere® Automation and Dashboards (Video 4:57)

CASSS 2022: A Streamlined Workflow for Rapid Charge Variant Analysis of Cetuximab innovator and two biosimilars by Microchip CE-MS with Data Analysis

CASSS 2022: Oligonucleotide Analysis by Mass Spectrometry: Accurate Annotation of Fragmentation Spectra

FOB 2022: Streamlining CQA analysis of Biosimilars and transforming information sharing across the globe

FOB 2022: Enabling a Multi-Attribute Method Comparison of Biosimilars

HUPO 2022: Accelerated O-glycopeptide search with isobaric filtering (Video 1:29)

HUPO 2022: N-Glycoproteomics MS/MS Data Analysis Benefits from Glycomics-lnformed Search Strategies

ASMS 2021: Analytical Characterization of Oligonucleotides by LC HRMS

ASMS 2021: Comprehensive Adeno-Associated Virus (AAV) Critical Quality Attribute Analysis with LC-MS (和訳版)

ASMS 2021: High-Throughput Product Quality Assessment of Protein Therapeutics on ZipChip-MS platform

ASMS 2021: Novel On-Chip Nebulizer for Reliable ESI andicIEF-MS BasedCharge Variant Identificationof Biopharmaceuticals

ASMS 2021: Mapping the Epitope Interactions and Conformational Changes to HER2 upon Herceptin Binding using Plasma Induced Modification of Biomolecules (PLIMB)

ASMS 2021: RapidFire-MS (RF-MS) as an Alternative to LC-MS for Rapid Assessment of Glycoforms in Therapeutic Antibodies

ASMS 2021: The Utility of Nanoparticle Protein Coronas for Studying the Plasma Glycoproteome

ASMS 2021: Applications of electron activated dissociation for next-generation biotherapeutic characterization

ASMS 2021: Assessing and Correcting for Electrospray Ionization Response of mAb Fragments Post Mass Deconvolution

ASMS 2021: High Throughput Biotherapeutic Glycosylation Profiling Using High Resolution Ion Mobility MS

ASMS 2021: Real Time Antibody Digestion by Rapid Flow Injection Mass Spectrometry

ASMS 2021: Kitted universal MAM: Automatable Sample Processing for all Stages of Biological Drugs

ASMS 2021: Multi-attribute Monitoring of Monoclonal Antibodies by icIEF-MS

Oligonucleotide Analysis by Mass Spectrometry Sequence Display and Automation is no longer a Sisyphean Task (Video)

Analytical Characterization of Oligonucleotides by Liquid Chromatography – (LC) High Resolution Mass Spectrometry (HRMS)

Oligonucleotide Analysis by Mass Spectrometry: Sequence Display and Automation is no longer a Sisyphean Task (和訳版)

Integrated software platform for analyzing hydrogen-deuterium exchange and oxidative footprinting data for solvent accessibility

Antibody De Novo Sequencing by LC MS/MS using Highly Automated Sample Preparation and Data Processing (Video)

ASMS2020: Use of PASEF for Accelerated Protein Sequence Confirmation and de novo Sequencing with High Data Quality

A Glycan Wildcard Search for Identifying Glycoprotemic Dark Matter (Video 3:07)

CASSS2020: Assaying Protein / Ligand Binding with High-Resolution Native Mass Spectrometry

CASSS2020: Wildcard™ and Diagnostic Ion Filtering to Find Unanticipated N- and O-linked Glycopeptides

ASMS2020: Assaying Protein / Ligand Binding with High-Resolution Native Mass Spectrometry

ASMS2020: Systematic examination of protein/glycopeptide extraction methods and MS/MS fragmentation techniques for milk glycoproteins survival across infant digestion

ASMS2020: MS/MS Filtering and Wildcard™ Searches for Novel N-and O-linked GlycopeptideIdentifications

ASMS2020: Reconstructing Protein Charge Heterogeneity from a Bottom-Up Approach

ASMS2020: Unravelling Hundreds of Proteoforms of Industrial Enzymes

ASMS2020: MS Characterization of Extensin Peptides from Cell Walls: Identification of Intra- and Intermolecular Cross-links and Abundance of Internal Fragment Ions

ASMS2020: Making LC-MS Sensibly Useful for Host Cell Protein Applications (和訳版)

ASMS2020: Evaluation of a New Software Tool For Assisting with the siRNA Metabolite Identification by LC-MS

ASMS2020: Ion Mobility Mass Spectrometry of Glyco- and Phospho-Peptides

ASMS2020: Cyclic Peptide Tandem-MS Search Software

Superposition of Orthogonal Methods – Intact Reconstruction from Peptide Mapping

ASMS2019: Charge Deconvolution and Automatic Sequence Matching for Oligonucleotides

HOS2019: Integrated Software Platform for Analyzing Hydrogen-Deuterium Exchange and Oxidative Footprinting Data Ebola

Glycobiology2018: Intact & Native Mass Analysis of Glycoproteins

Mapping the Interactions of PKNB with Small Molecule Inhibitors Using Plasma Induced Modifications of Biomolecules (PLIMB)

Determining solvent access of HNE adducted myoglobin with hydroxyl radicals generated from PLIMB

NIIMBL2019: Rapid Assessment of CQAs Using Imaged CIEF-MS for Real-Time Bioprocess Decision Making

ASMS2019: Charge Deconvolution of Surface-Induced-Dissociation (SID) Spectra of Protein Complexes

ASMS2019: Cleavage of Intact Monoclonal Antibodies by Cathepsins L and D Studied by Native Mass Spectrometry

ASMS2019: Isotope Selection in Label-Free Quantification and its Effects in Biopharmaceutical Characterization

Highly Automated Analysis of Antibody Chain Shuffling in Bispecific Antibodies (和訳版)

ASMS2018: Host Cell Proteins (HCPs) in Plasma-Derived Biotherapeutics

CASSS2018: High Throughput LC-MS Analysis of Intact Light and Heavy Chain Supporting mAb Screening and Cell Line Characterization

CASSS2018: Streamlined MAM for New Peak Detection, Comprehensive Data Inspection, and Confident Reporting

CASSS2018: Automatic N-Glycan Analysis of Therapeutic Glycoproteins using Byos Vendor-Neutral Software

HUPO2018: Charge Deconvolution of Hard-to-Deconvolve Mass Spectra

WCBP2018: Host Cell Proteins (HCPs) in Plasma-Derived Biotherapeutics

WCBP2018: Multi-Attribute Comparison of Innovator and Biosimilar Filgrastim

ASMS2018: Automatic End-to-End De Novo Sequencing (including I/L) of Antibodies with EThcD Fragmentation

ASMS2018: Integrated Software Platform for Analyzing Hydrogen-Deuterium Exchange and Oxidative Footprinting Data West Nile Virus

ASMS2018: Automatic Detection of Clipped Monoclonal Antibodies from High-Resolution Native Mass Spectrometry

PEGS2018: Antibody Analysis with Native Mass Spectrometry and Parsimonious Charge Deconvolution

WCBP2018: Antibody Analysis with Native Mass Spectrometry and Parsimonious Charge Deconvolution

ASMS2017: Analytical Characterization and Comparison of Filgrastim and Its Biosimilar

WCBP2017: Multi-attribute Method Comparison of Infliximab

WCBP2017: Harmonizing Physicochemical Characteristics

ASMS2015: Rapid Identification and Quantitation of Disulfide Bonds in Infliximab (Remicadevs Remsima)

Warren Workshop 2014: Byonic™ Glycopeptide Analysis

ASMS2014: Preview–>Byonic™ Workflow

ASMS2014: Top-down Analysis with Byonic™

ASMS2013: Byonic™ Phospho & Glycopeptides

Toward chemical footprinting at residue resolution: FPOP data analysis of IL23 – antibody binding

Assaying Protein / Ligand Binding with High-Resolution Native Mass Spectrometry

Simplified and automated analysis of the highly glycosylated therapeutic protein Erythropoietin (Video Poster 4:55)

Complex glycoprotein characterization using CE-MS and Automated Analysis

Challenges and Strategies in Glycan Analysis by MAM

TIDES2024: Oligonucleotide Samples are Amenable to Automated LCMS Analysis

A Novel in vitro Serum Stability Assay for Antibody Therapeutics incorporating Internal Standards (Video 6:56)

IRT 2024: Optimization of a Liquid Chromatography-Tandem Mass Spectrometry mRNA Sequence Mapping Workflow

CASSS 2024: Charge Variant Mass Spectrometry for Analysis of Biotherapeutics with Orthogonal and Fractionated Sampling

CASSS 2024: Automated Spectrum Annotation and Structure Disambiguation of Released N-linked Glycans

CASSS 2024: A Middle-Level Approach to Simplify Sample Preparation and Data Analysis for Characterization of the Fusion Protein Blinatumomab

CASSS 2024: Advancements in Multi-Protein Quantitation for Host Cell Protein Discovery copy

CASSS 2024: Digested Oligonucleotide IP-RPLC-MS/MS Characterization of mRNA Sequence, 5’ Cap, and 3’ PolyATail

Peak Filtering, Peak Annotation, and Wildcard Search for Glycoproteomics

Vulnerabilities in coronavirus glycan shields despite extensive glycosylation

TBK1 phosphorylates mutant Huntingtin and suppresses its aggregation and toxicity in Huntington’s disease models

Exploring sample preparation and data evaluation strategies for enhanced identification of host cell proteins in drug products of therapeutic antibodies and Fc-fusion proteins

Site-specific analysis of the SARS-CoV-2 glycan shield

Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag)

Optimal Dissociation Methods Differ for N- and O-Glycopeptides

Automated Antibody De Novo Sequencing and Its Utility in Biopharmaceutical Discovery

Localization of Protein Complex Bound Ligands by Surface-Induced Dissociation High-Resolution Mass Spectrometry

Development of an LC-MS/MS peptide mapping protocol for the NISTmAb

Identification of Sialic Acid Linkages on Intact Glycopeptides via Different Chemical Modification Using IntactGIG-HILIC

Parsimonious Charge Deconvolution for Native Mass Spectrometry

Biosimilarity under stress: A forced degradation study of Remicade® and Remsima™

A Multidimensional Analytical Comparison of Remicade and the Biosimilar Remsima

Extended O-GlcNAc on HLA Class-I-Bound Peptides

Characterization of Drug-Product-Related Impurities and Variants of a Therapeutic Monoclonal Antibody by Higher Energy C-Trap Dissociation Mass Spectrometry

Polylactosaminoglycan glycomics: enhancing the detection of high molecular weight N-glycans in MALDI-TOF profiles by matched filtering

Glycoproteomic analysis of the secretome of human endothelial cells

Byonic™ advanced peptide and protein identification software

Constrained de novo sequencing of conotoxins

Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis

Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations

Preview: A Program for Surveying Shotgun Proteomics Tandem Mass Spectrometry Data

Recent developments in quantitative proteomics

Protein standard absolute quantification (PSAQ) method for the measurement of cellular ubiquitin pools

Comment on “Unbiased statistical analysis for multi-stage proteomic search strategies”

Two-dimensional target decoy strategy for shotgun proteomics

Conversion of methionine into homocysteic acid in heavily oxidized proteomics samples

Elucidating in vivo structural dynamics in integral membrane protein by hydroxyl radical footprinting

Glycan family analysis for deducing N-glycan topology from single MS

Automated N-glycopeptide identification using a combination of single- and tandem-MS

Lookup peaks: a hybrid of de novo sequencing and database search for protein identification by tandem mass spectrometry

An embeddable molecular code for Lewis X modification through interaction with fucosyltransferase 9

Ultraviolet Photodissociation and Activated Electron Photodetachment Mass Spectrometry for Top-Down Sequencing of Modified Oligoribonucleotides

Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis

Attribute Analytics Performance Metrics from the MAM Consortium Interlaboratory Study

Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

Ultrasensitive Characterization of Charge Heterogeneity of Therapeutic Monoclonal Antibodies Using Strong Cation Exchange Chromatography Coupled to Native Mass Spectrometry

An Integrated Proteomic and Glycoproteomic Investigation Reveals Alterations in the N-Glycoproteomic Network Induced by 2-Deoxy-D-Glucose in Colorectal Cancer Cells

Structure of the hepatitis C virus E1E2 glycoprotein complex

Microflow Liquid Chromatography Coupled to Mass Spectrometry (μLC–MS) Workflow for O-Glycopeptides Isomers Analysis Combining Differential Mobility Spectrometry and Collision Induced and Electron Capture Dissociation

Extending Proteome Coverage by Combining MS/MS Methods and a Modified Bioinformatics Platform Adapted for Database Searching of Positive and Negative Polarity 193 nm Ultraviolet Photodissociation Mass Spectra

Development of Software Workflow for the Rapid Detection of Cross-Linked Dipeptides

Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species

High-Sensitivity and High-Resolution Therapeutic Antibody Charge Variant and Impurity Characterization by Microfluidic Native Capillary Electrophoresis-Mass Spectrometry

Residue-Specific Impact of EDTA and Methionine on Protein Oxidation in Biotherapeutics Formulations Using an Integrated Biotherapeutics Drug Product Development Workflow

Sample Preparation Matters for Peptide Mapping to Evaluate Deamidation of Adeno-Associated Virus Capsid Proteins Using Liquid Chromatography-Tandem Mass Spectrometry

Optimized Multi-Attribute Method Workflow Addressing Missed Cleavages and Chromatographic Tailing Carry-Over of Hydrophobic Peptides

A competitive binding-mass spectrometry strategy for high-throughput evaluation of potential critical quality attributes of therapeutic monoclonal antibodies

Rapid Characterization of Antibodies via Automated Flow Injection Coupled with Online Microdroplet Reactions and Native-pH Mass Spectrometry

Diversity Matters: Optimal Collision Energies for Tandem Mass Spectrometric Analysis of a Large Set of N-Glycopeptides

Physicochemical characterization and functionality comparison of Humira® (adalimumab), Remicade® (infliximab) and Simponi Aria® (golimumab)

Using New Peak Detection to Solve Sequence Variants Analysis Challenges in Bioprocess Development

Higher-Order Structure Characterization of NKG2A/CD94 Protein Complex and Anti-NKG2A Antibody Binding Epitopes by Mass Spectrometry-Based Protein Footprinting Strategies

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

“Lab of the Future”-Today: Fully Automated System for High- Throughput Mass Spectrometry Analysis of Biotherapeutics

A Highly Efficient Workflow for Detecting and Identifying Sequence Variants in Therapeutic Proteins with a High Resolution LC-MS/MS Method

Label-free shotgun proteomics: Exploiting a reliable and sensitive method to monitor residual host-cell proteins in monoclonal antibody products

Identification of Hetero-aggregates in Antibody Co-formulations by Multi-dimensional Liquid Chromatography Coupled to Mass Spectrometry

Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth PTPRZ glycosylation regulates glioma growth

Investigation of high molecular weight size variant formation in antibody-drug conjugates: microbial transglutaminase-mediated crosslinking

Impact of Trisulfide on the Structure and Function of Different Antibody Constructs

Determination of drug-to-antibody ratio of antibody-drug conjugate in biological samples using microflow-liquid chromatography-high-resolution mass spectrometry

Discovery and Characterization of an Acid-Labile Serine-Lysine Cross-Link in Antibody High-Molecular-Weight Species Using a Multipronged Mass Spectrometry Approach

Agilent – Host Cell Protein Analysis Using Agilent AssayMAP Bravo and 6545XT AdvanceBio LC/Q-TOF

Atypical Asparagine Deamidation of NW Motif Significantly Attenuates the Biological Activities of an Antibody Drug Conjugate

Site-Specific Structural Changes in Long-Term-Stressed Monoclonal Antibody Revealed with DEPC Covalent-Labeling and Quantitative Mass Spectrometry

Differential T cell immune responses to deamidated adeno-associated virus vector

Site Specific glycan analysis of the SARS-Cov2 Virus spike

Fully automated peptide mapping multi-attribute method by liquid chromatography–mass spectrometry with robotic liquid handling system

Mapping the SARS-CoV-2 spike glycoprotein-derived peptidome presented by HLA class II on dendritic cells

Hydroxyl radical mediated damage of proteins in low oxygen solution investigated using X-ray footprinting mass spectrometry

Mapping and Quantification of Over 2000 O-linked Glycopeptides in Activated Human T Cells with Isotope-Targeted Glycoproteomics (Isotag)

Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

Identification and quantification of chain-pairing variants or mispaired species of asymmetric monovalent bispecific IgG1 monoclonal antibody format using reverse-phase polyphenyl chromatography coupled electrospray ionization mass spectrometry

Enrichment strategy and initial characterization of heterodimers enriched from a co-formulated cocktail of therapeutic antibodies against SARSCOV-2

Intact quantitation of cysteine-conjugated antibody-drug conjugates using native mass spectrometry

Insight into the Degradation Pathways of an AAV9

Orthogonal Comparison of Analytical Methods by Theoretical Reconstruction from Bottom-up Assay Data

Dragonfly Therapeutics – De Novo Sequencing

Immuto Scientific – PLIMB – Plasma Induced Modification of Biomolecules

Unravelling the glycosylation of the SARS-CoV-2 spike protein

Unexpected Modifications in Cell-Line Characterization

Automated Data Filtering for Rapid Sample Comparison of Human Milk Glycoproteins

Specific and Confident Glycation Site Mapping in Therapeutic Proteins Using Automated Data Processing

Mass Spectrometry-Based De Novo Sequencing of Monoclonal Antibodies Using Multiple Proteases and a Dual Fragmentation Scheme

Rapid Detection of Cross-Linked Dipeptides

Chemical probing provides insight into the native assembly state of a bacterial microcompartment

Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

Sample Preparation Matters for Peptide Mapping to Evaluate Deamidation of Adeno-Associated Virus Capsid Proteins Using Liquid Chromatography-Tandem Mass Spectrometry (中译版)

Rapid Detection of Cross-Linked Dipeptides

Proteomic Analysis of Adenovirus 5 by UHPLC-MS/MS: Development of a Robust and Reproducible Sample Preparation Workflow

Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

BEBPA 2023 Host Cell Protein Conference – In Review

Automated Characterization of Biotherapeutics via Hardware, Software and Chemistry

Unanticipated N- and O- Glycopeptides

Optimization of a Label-Free Peptide Quantitation Strategy for Analysis of Therapeutic Proteins

Comparative Analysis of Herceptin N-Linked Glycosylation by HILIC-FLD and LC- MS/MS Methods

Advanced Techniques in Protein Glycosylation Analysis Using Mass Spectrometry

A Novel in vitro Serum Stability Assay for Antibody Therapeutics incorporating Internal Standards

Accurate prediction of antibody deamidations by combining high-throughput automated peptide mapping and pre-trained protein language model-based deep learning

Utilization of Intact Reconstruction to Characterize Bi-specific Antibodies

Insights 1: Modification Fine Control in Byonic™ (和訳版)

Insights 2: Quantifying Aspartic Acid Isomerization in Byos® (和訳版)

Insights 3: Intact Deconvolution with Isotopic Resolution, Intact Reconstruction in Byos® (和訳版)

Insights 4: Dynamic Columns, XIC Area Summed isoX Normalized in Byos® (和訳版)

Insights 5: MS1 Correlation Colors (和訳版)

Insights 6: Cleavage Flags in Byonic™ (和訳版)

Insights 7: Reporting Basics in Byos® (和訳版)

Insights 8: Mapping In Silico Peptides, Intact Monoisotopic Mass Visualization in Byos®

Insights 9: Delta Mod Score for Variant Analyses in Byos® and Byonic™

Insights 10: Intact Mass Workflows, Automated Annotations in Deconvoluted Spectra in Byos®

Insights 11: Validating Glycopeptide Results, MSMS Filtering in Byonic™

Insights 12: Accelerating Sequence Variant Analysis with Byos® Validators

Insights 13: Charge Deconvolution Using Know Mass Delta

Insights 14: Detached Glycan

Insights 15: Multi-Attribute Method (MAM)

Insights 16: Peptide Manager

Insights 17: Controlling how protein homology is represented in Byos

Insights 18: Using Metadata and Queries Byosphere®

Insights 19: Native MS Deconvolution

Insights 20: Glycan Cartoons in Byos

Insights 21: Investigating Unknown Mass Peaks in Byos

Insights 22: Statistics in Reports

Insights 23: Oligonucleotide Building Blocks Basics

Insights 24: Quantification of Modifications in the Peptide Workflows

Insights 25: Oligonucleotide and Impurity UV-MS Quantitation

Insights 26: Released Glycan Fragmentation

new Insights 27: Digested Oligonucleotides Workflow

new Intact Oligonucleotide Analysis

new Multi-Protein Quantitation

new Reconstruction

new HDX Analysis