Featured Resources
PTM Analysis – How to Marry Speed and Confidence in R&D

John Reed covers the ins and outs of PTM analysis. He touches on peptide identification and the use of standard curves and weighted averaging of XICs - and a little bit of ice cream.

Automated Feedback Control of Protein Characteristics in a Perfusion Bioprocess

“Open-loop control” is standard control strategy for biomanufacturing – Critical Quality Attributes (CQAs) are maintained within set ranges by controlling Critical Process Parameters (CPPs). Mass spectrometry is an ideal tool for PAT.

EPO: Separation and Analysis

EPO has also been historically very difficult to characterize by traditional approaches. Looking for a faster, simpler way of separating and analyzing?

EU UGM 2022 – LC-MS and LC-MS/MS Analyses of Adeno-Associated Viruses Anc80

Jerome Jonveaux describes peptide and intact workflows developed for quantification of PTMs and comparison of AAV samples

Tackling the Glycan Isomer Challenge for your Biotherapeutics

As minor changes to production processes can influence both glycan structure and composition, glycans must be monitored. However, characterization of N-linked glycosylation is analytically challenging due to innate glycan microheterogeneity.

EU UGM 2023: Enhancing the Dimensionality of Glycoproteomics

Can sample pretreatment hide biologically important glycan species? Can Ion mobility be used to boost glycopeptide detction?

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