Featured Resources
1:00:51
PTM Analysis – How to Marry Speed and Confidence in R&D

John Reed covers the ins and outs of PTM analysis. He touches on peptide identification and the use of standard curves and weighted averaging of XICs - and a little bit of ice cream.

20:15
Automated Feedback Control of Protein Characteristics in a Perfusion Bioprocess

“Open-loop control” is standard control strategy for biomanufacturing – Critical Quality Attributes (CQAs) are maintained within set ranges by controlling Critical Process Parameters (CPPs). Mass spectrometry is an ideal tool for PAT.

54:45
EPO: Separation and Analysis

EPO has also been historically very difficult to characterize by traditional approaches. Looking for a faster, simpler way of separating and analyzing?

18:56
EU UGM 2022 – LC-MS and LC-MS/MS Analyses of Adeno-Associated Viruses Anc80

Jerome Jonveaux describes peptide and intact workflows developed for quantification of PTMs and comparison of AAV samples

38:23
Tackling the Glycan Isomer Challenge for your Biotherapeutics

As minor changes to production processes can influence both glycan structure and composition, glycans must be monitored. However, characterization of N-linked glycosylation is analytically challenging due to innate glycan microheterogeneity.

33:27
EU UGM 2023: Enhancing the Dimensionality of Glycoproteomics

Can sample pretreatment hide biologically important glycan species? Can Ion mobility be used to boost glycopeptide detction?

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