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18:47
Three Channel Charge Deconvolution

There are two quite different methods for determining the charge of m/z peaks:  peak spacing for isotope-resolved masses, and ratio relations among peaks for isotope-unresolved masses. Most software uses one method or the other, but Protein Metrics Intact Mass can use both information channels simultaneously, as well as a third channel...
17:24
Database Search of Tandem Mass Spectrometry of Oligonucleotides

In collaboration with the University of Texas at Austin, Rose discusses MS1 and MS2 analysis of oligonucleotides and the application of Byonic proteomics features for these molecules
57:17
Bispecific MS Analysis and Cell Line Development

Unlock the complexities of Bispecific Analysis and immediately share simple to understand visualizations with others? That's exactly what Janssen's cell line development group have done. Come and find out how.
37:51
Intact Profiling and Visualization of Urinary Prostate-Specific Antigen Profiles

Alan Moran presents a customized intact protein workflow for the analysis of intact PSA, exploring its N-glycome as well as other PSA proteoforms. An easier, faster, and more efficient data analysis and processing of clinically relevant PSA proteoforms is achieved.
5:04
Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

By performing a semi-automated mass spectrometry method for characterizing disulfide bonds, as well as the SEC and SDS-PAGE methods, the authors were able to more seamlessly identify how bevacizumab and rituximab differ in their disulfide bond profile and degradation propensity.

5:37
Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability

A panel of stress conditions ( including temperature, pH, oxidizing agents, and forced glycation) were applied to identify and functionally evaluate critical quality attributes in the complementary-determining and conserved regions of a bispecific antibody was applied in this study.
19:15
EU UGM 2023: Byosphere assisted biopharmaceutical development

Moving to a centralized architecture for streamlining data management, integrity and traceability. Lessons learned from a Byosphere installation.
54:23
Neutrophil azurophilic granule glycoproteins – atypical glycans

Glycoproteomics analysis of complex samples. What is the Impact of sample preparation, mass spectrometry and data analysis on your observed glycoproteome?
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