Presented by Bristol Meyers Squibb and Protein Metrics. A roadmap for successful implementation of PAT tools - identification of critical quality attributes and critical control points of the bioprocess for efficient and smarter development.
By using bottom-up data to build a theoretical reconstruction of the intact data and then juxtaposing it with the experimental intact data, differences and similarities between the two orthogonal methods can quickly be qualitatively determined.
Seamlessly move between non-GxP and GxP to satisfy regulatory requirements with Byosphere. Regardless of the mass spec platform scientists can create workflows that allow comparisons with speed and with confidence
“Open-loop control” is standard control strategy for biomanufacturing – Critical Quality Attributes (CQAs) are maintained within set ranges by controlling Critical Process Parameters (CPPs). Mass spectrometry is an ideal tool for PAT.
In this talk, Dr Carlson reviews recent updates to the Protein Metrics platform and talk about the “next steps” of informing MS-level experiments with information from biology and process, as well as what all mass spectrometrists already proclaim, that we can inform biology in reverse.
Comparing batches? Assessing digestion completion? Tracking over-alkylation? Learn about the rational for the types of dashboard constructed to monitor these important aspects of laboratory operations.
For fast ranking during expression vector design and clone selection, Lonza's setup for high throughput intact MS uses Protein Metric’s parsimonious charge deconvolution algorithm.
The latest on our Oligo workflows including long digested oligonucleotides - especially mRNAs
Microflow Liquid Chromatography Coupled to Mass Spectrometry (μLC–MS) Workflow for O-Glycopeptides Isomers Analysis Combining Differential Mobility Spectrometry and Collision Induced and Electron Capture Dissociation
Extending Proteome Coverage by Combining MS/MS Methods and a Modified Bioinformatics Platform Adapted for Database Searching of Positive and Negative Polarity 193 nm Ultraviolet Photodissociation Mass Spectra