Featured Resources
25:06
Assigning function to the structure of HIV and SARS-CoV-2 glycan shields

Weston Struwe of the University of Oxford describes the analysis of HIV and SARS-CoV-2 viral spikes and illustrate how glycomics/ glycoproteomics datasets can inform on their structural assembly and biological functions.

41.26
Unraveling the Twin Tales of Biosimilar and Innovator Glycans

N-glycans are omnipresent in the Fc region of monoclonal antibody products. Modifications to a glycan profile can impact a protein’s stability/folding, binding affinities, effector functions, clearance rates, and/or immunogenicity.

49:25
Automation of Glycan and Peptide Mapping and Improving Efficiency and Quality

More samples, more tests and more complex modalities. Sound familiar? As Pfizer increased the number of assays to perform, Thomas Powers underscores that it is also critical to automate original routine assays and describes challenges tackled along the path.

20:15
Automated Feedback Control of Protein Characteristics in a Perfusion Bioprocess

“Open-loop control” is standard control strategy for biomanufacturing – Critical Quality Attributes (CQAs) are maintained within set ranges by controlling Critical Process Parameters (CPPs). Mass spectrometry is an ideal tool for PAT.

17:26
Generating Wisdom from Raw Data

From wine, to marsupials to viruses. The amount of work happening today to understand biology has and will continue to exponentially increase. Join us for an overview to the universe of protein problems that Protein Metrics is involved with understanding.

34:46
High throughput screening and data analysis using Native Mass Spectrometry and Byos

Under carefully optimized instrumental conditions it is feasible to quantify the drug dissociation constant (Kd). OMass Therapeutics presents in house high-throughput native MS screening platform combined with high-throughput data processing.

33:32
Characterizing the glycan shield of the Hepatitis C E1E2 glycoprotein complex using mass spectrometry

Maddy Newby takes us through the steps for unravelling the structural details of the E1E2 glycoprotein complex whilst also uncovering a novel glycan site within a non-canonical N-linked glycan site.

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