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25:06
Assigning function to the structure of HIV and SARS-CoV-2 glycan shields

Weston Struwe of the University of Oxford describes the analysis of HIV and SARS-CoV-2 viral spikes and illustrate how glycomics/ glycoproteomics datasets can inform on their structural assembly and biological functions.

5:34
MS-Based De Novo Sequencing of mAbs Using Multiple Proteases and a Dual Fragmentation Scheme

By using multiple proteases and dual fragmentation the authors are able to get the most accurate sequences and the best depth of coverage whilst optimizing protocols for de novo antibody sequencing

56:09
How to Advance Your Host Cell Protein Analysis with Mass Spectrometry

What problem HCPs should you look for? When to implement MS analysis of HCPs in product development? How to use MS to complement other analytical techniques? Kevin van Cott has the answers...
17:26
Generating Wisdom from Raw Data

From wine, to marsupials to viruses. The amount of work happening today to understand biology has and will continue to exponentially increase. Join us for an overview to the universe of protein problems that Protein Metrics is involved with understanding.
37:51
Intact Profiling and Visualization of Urinary Prostate-Specific Antigen Profiles

Alan Moran presents a customized intact protein workflow for the analysis of intact PSA, exploring its N-glycome as well as other PSA proteoforms. An easier, faster, and more efficient data analysis and processing of clinically relevant PSA proteoforms is achieved.
5:04
Streamlining the Characterization of Disulfide Bond Shuffling and Protein Degradation in IgG1 Biopharmaceuticals Under Native and Stressed Conditions

By performing a semi-automated mass spectrometry method for characterizing disulfide bonds, as well as the SEC and SDS-PAGE methods, the authors were able to more seamlessly identify how bevacizumab and rituximab differ in their disulfide bond profile and degradation propensity.

33:32
Characterizing the glycan shield of the Hepatitis C E1E2 glycoprotein complex using mass spectrometry

Maddy Newby takes us through the steps for unravelling the structural details of the E1E2 glycoprotein complex whilst also uncovering a novel glycan site within a non-canonical N-linked glycan site.

42:43
From Here to Byosphere

A Global Biotherapeutic CDMO’s approach to Mass Spectrometry data processing
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